Drugs and Adverse effects

Drugs and Adverse effects

Drugs specific adverse effect :::

ü Vanishing bile duct syndome -- chlorpromazine

ü Coronary steal phenomena -- dipyridamole and isoflurane

ü Toxic ambylopia --- ethambutol

ü Fatal myocarditis ---clozapine

ü Idiosyncratic hepatic necrosis in infant --sodium valproate

ü Pseudo porphyria -- piroxicam

ü Amotivational syndrome-- marijuana

ü Fetal aplasia cutis -- carbimazole/methimazole in pregnancy

ü Drug induced mysthenia gravis-- d- penicilamine

ü Salt and pepper fundus -- thioridazine

ü Blue halo effect -- sidenafil

ü Calciphylaxis -- warfarin use in hemodylasis pt

ü Livedo reticularis -- amantidine

ü DRESS ie drug related eosinophila and systemic symptoms -- allopurinol

ü Pseudolymphoma syndrome -- anticonvulsants

ü Delayed bone marrow suppresion --nitrosourea anticancer drugs

ü Predisposition to listeria infection -- fludarabine

ü FSGS --heroin

ü Peripheral neuropathy resembling motor neuron disease -- dapsone

ü Vacuolar myopathy -- vincristine

ü Acute hepatic necrosis in pregnancy -- tetracycline

ü Cytokine release syndrome --muromonab cd3

ü Hand foot syndrome -- capcitabine

ü Hemorragic cystitis -- ifosfamide

ü  Haemolytic uremic syndrome -- mitomycine c